Abstract:
The thyroid gland pathologies occupy one of the
leading places among endocrine disorders. Metabolic
changes that occur in hyper- or hypothyroidism lead to
dysfunction of many organs and systems, first of all, the
cardiovascular system. Cardiovascular diseases are one
of the most acute medical and social problems of modern society. Currently, it has been established that an
increase in homocysteine levels has a significant role in
the progression of coronary heart disease and its complications. However, several scientific publications do
not sufficiently address the impact of hyperhomocysteinemia on the functional myocardium condition in thyroid pathology, which requires a more detailed study of
this problem. The study aimed to establish the reorganization of the structural components of the myocardium
under the conditions of experimental hyperhomocysteinemia on the background of hyper- and hypothyroidism. Histological examination of left ventricle pieces of
the rat’s heart was conducted in the study. Significant
microscopic changes of stromal-vascular-parenchymal
components were found in the myocardium of laboratory rats with HHCy, hyper-, and hypothyroidism. More
pronounced necrotic and degenerative changes of cardiomyocytes have been established in the conditions
of combined hyper- and HHCy and hypothyroidism and
HHCy action.
