Morphological features of the myocardium in hyperhomocysthinemia on the background of thyroid disorders

Abstract

The thyroid gland pathologies occupy one of the leading places among endocrine disorders. Metabolic changes that occur in hyper- or hypothyroidism lead to dysfunction of many organs and systems, first of all, the cardiovascular system. Cardiovascular diseases are one of the most acute medical and social problems of modern society. Currently, it has been established that an increase in homocysteine levels has a significant role in the progression of coronary heart disease and its complications. However, several scientific publications do not sufficiently address the impact of hyperhomocysteinemia on the functional myocardium condition in thyroid pathology, which requires a more detailed study of this problem. The study aimed to establish the reorganization of the structural components of the myocardium under the conditions of experimental hyperhomocysteinemia on the background of hyper- and hypothyroidism. Histological examination of left ventricle pieces of the rat’s heart was conducted in the study. Significant microscopic changes of stromal-vascular-parenchymal components were found in the myocardium of laboratory rats with HHCy, hyper-, and hypothyroidism. More pronounced necrotic and degenerative changes of cardiomyocytes have been established in the conditions of combined hyper- and HHCy and hypothyroidism and HHCy action.