Study of hypoglycemic activity of antidiabetic herbal mixture on streptozotocin-nicotinamide-induced rat model of type 2 diabetes

Abstract

Diabetes is a global problem today, as the number of patients in the world increases sharply every year. Severe complications of diabetes are very dangerous, as they can lead to disability and high mortality. The purpose of the study was to establish the hypoglycemic property of new herbal mixture (Equiseti arvensis herba, Sambuci flores, Inulae rhizomata et radices, Hyperici herba, Tiliae flores, Polygoni avicularis herba, Myrtilli folium, Urticae folia) in streptozotocin-nicotinamide-induced diabetic rats. Experimental diabetes type 2 was reproduced on male albino rats of the Wistar strain by injection of streptozotocin (65 mg/kg) and nicotinamide (230 mg/kg). The results showed that the use of antidiabetic herbal mixture for four weeks reduced the severity of hyperglycemia, prevented the development of secondary insulin resistance and increased glucose tolerance in rats with streptozotocin-nicotinamide-induced diabetes mellitus, which was manifested by an increase of coefficient of sensitivity to insulin and a decrease of hyperglycemia to baseline during the intraperitoneal glucose tolerance test.