Abstract:
Diabetes is a global problem today, as the number of patients in the world increases sharply every
year. Severe complications of diabetes are very dangerous, as they can lead to disability and high
mortality.
The purpose of the study was to establish the hypoglycemic property of new herbal mixture
(Equiseti arvensis herba, Sambuci flores, Inulae rhizomata et radices, Hyperici herba, Tiliae flores, Polygoni
avicularis herba, Myrtilli folium, Urticae folia) in streptozotocin-nicotinamide-induced diabetic rats.
Experimental diabetes type 2 was reproduced on male albino rats of the Wistar strain by injection of
streptozotocin (65 mg/kg) and nicotinamide (230 mg/kg).
The results showed that the use of antidiabetic herbal mixture for four weeks reduced the severity
of hyperglycemia, prevented the development of secondary insulin resistance and increased glucose
tolerance in rats with streptozotocin-nicotinamide-induced diabetes mellitus, which was manifested by
an increase of coefficient of sensitivity to insulin and a decrease of hyperglycemia to baseline during
the intraperitoneal glucose tolerance test.
