Аннотации:
Objective: The aim of the work was the histological study of a corrective influence of sodium 2-((4-
amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl) thio) acetate on the state of rats liver under conditions of
acute immobilization stress.
Material and Method: As an object of research sodium 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-
triazol-3-yl) thio) acetate was used. All substances were injected intragastrically, daily for 5 days in appropriate
doses on an empty stomach from 9.00-10.00. 1 hour after the last injection, immobilization 6-hour stress was
simulated. The central part of the liver was fixed for further histological examination in 10% formaldehyde
solution, dehydrated in alcohols of increasing strength, poured into paraffin.
Result and Discussion: The results of the study demonstrate the presence of stress-protective properties
of sodium 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl) thio) acetate in the model of acute
immobilization stress, which was reproduced for 6 hours. As can be seen from the described and presented
microscopic picture, the test sample to some extent reduced the degree of stress damage to the liver. In terms
of the positive effect on the histological condition of the liver parenchyma (a more pronounced structural
orientation of hepatocytes was noted, their beam structure was contoured, dystrophic changes of hepatocytes
are less pronounced, round cell infiltrates and foci of hepatocyte necrosis are absent), sodium 2-((4-amino-5-
(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)acetate exhibits a stress-protective effect in the model of acute
immobilization stress. We can conclude about similarity of activity of the test sample with comparison drug
(Mebicar®) at studying of influence on a histologic condition of a liver parenchyma
