Method for creating conditions to induce its intrinsic ulcerogenic effect of diclofenac (a non-steroidal anti-inflammatory drug) in experimental studies on rats

Małgorzata, М. М.; Simonova, I. V.

dc.contributor.author	Małgorzata, М. М.
dc.contributor.author	Simonova, I. V.
dc.date.accessioned	2025-05-01T12:45:45Z
dc.date.available	2025-05-01T12:45:45Z
dc.date.issued	2024
dc.identifier.citation	Małgorzata М. М. Method for creating conditions to induce its intrinsic ulcerogenic effect of diclofenac (a non-steroidal anti-inflammatory drug) in experimental studies on rats / M. M. Białoszycka, I. V. Simonova // Молодь: наука та інновації : тези доп. XIІ Міжнародної наук.-техн. конф. студентів, аспірантів та молодих вчених, м. Дніпро, 13-15 листоп. 2024 р. – Дніпро : НТУ «ДП», 2024. – Т. 3. – С. 264.	uk_UA
dc.identifier.uri	https://dspace.vnmu.edu.ua/123456789/9851
dc.description.abstract	This study presents a method for inducing the intrinsic ulcerogenic effect of diclofenac, a non-steroidal anti-inflammatory drug (NSAID), in experimental rats. To enhance diclofenac's ulcerative potential, an aqueous suspension of high-dispersion silica was administered prior to drug intake to neutralize gastric mucosal protection. The experiment involved 30 Wistar rats divided into three groups, including a control group, a group receiving diclofenac alone, and a group pretreated with silica. The silica pretreatment resulted in significantly more severe gastric ulceration, validating the model's effectiveness in replicating NSAID-induced gastric damage for further experimental investigation	uk_UA
dc.language.iso	en	uk_UA
dc.publisher	м. Дніпро, НТУ «ДП»,	uk_UA
dc.subject	diclofenac	uk_UA
dc.subject	NSAIDs	uk_UA
dc.subject	ulcerogenic effect	uk_UA
dc.subject	gastric mucosa	uk_UA
dc.subject	experimental ulcer model	uk_UA
dc.subject	rats	uk_UA
dc.subject	high-dispersion silica	uk_UA
dc.subject	mucin adsorption	uk_UA
dc.subject	subchronic administration	uk_UA
dc.subject	gastrointestinal toxicity	uk_UA
dc.subject	protective mucus	uk_UA
dc.subject	ulceration assessment	uk_UA
dc.title	Method for creating conditions to induce its intrinsic ulcerogenic effect of diclofenac (a non-steroidal anti-inflammatory drug) in experimental studies on rats	uk_UA
dc.type	Thesis	uk_UA