Method for creating conditions to induce its intrinsic ulcerogenic effect of diclofenac (a non-steroidal anti-inflammatory drug) in experimental studies on rats

Białoszycka M. M.; Simonova, I. V.

dc.contributor.author	Białoszycka M. M.	pol
dc.contributor.author	Simonova, I. V.	en
dc.date.accessioned	2025-05-01T12:45:45Z
dc.date.available	2025-05-01T12:45:45Z
dc.date.issued	2024
dc.identifier.citation	Białoszycka М. М. Method for creating conditions to induce its intrinsic ulcerogenic effect of diclofenac (a non-steroidal anti-inflammatory drug) in experimental studies on rats / M. M. Białoszycka, I. V. Simonova // Молодь: наука та інновації : тези доп. XIІ Міжнародної наук.-техн. конф. студентів, аспірантів та молодих вчених, Дніпро, 13-15 листоп. 2024 р. – Дніпро, 2024. – Т. 3. – С. 264.	uk_UA
dc.identifier.uri	https://dspace.vnmu.edu.ua/123456789/9851	en
dc.description.abstract	This study presents a method for inducing the intrinsic ulcerogenic effect of diclofenac, a non-steroidal anti-inflammatory drug (NSAID), in experimental rats. To enhance diclofenac's ulcerative potential, an aqueous suspension of high-dispersion silica was administered prior to drug intake to neutralize gastric mucosal protection. The experiment involved 30 Wistar rats divided into three groups, including a control group, a group receiving diclofenac alone, and a group pretreated with silica. The silica pretreatment resulted in significantly more severe gastric ulceration, validating the model's effectiveness in replicating NSAID-induced gastric damage for further experimental investigation	en
dc.language.iso	en	en
dc.subject	diclofenac	en
dc.subject	NSAIDs	en
dc.subject	ulcerogenic effect	en
dc.subject	gastric mucosa	en
dc.subject	experimental ulcer model	en
dc.subject	rats	en
dc.subject	high-dispersion silica	en
dc.subject	mucin adsorption	en
dc.subject	subchronic administration	en
dc.subject	gastrointestinal toxicity	en
dc.subject	protective mucus	en
dc.subject	ulceration assessment	en
dc.title	Method for creating conditions to induce its intrinsic ulcerogenic effect of diclofenac (a non-steroidal anti-inflammatory drug) in experimental studies on rats	en
dc.type	Thesis	en