Abstract:
As of today, there is no effective method for treating the fetoplacental dysfunction (FPD) in pregnant women withpreeclampsia. The aim of research was the study of the method proposed by the authors for restoring the functional activity of thefetoplacental complex in pregnant women with FPD on the background of treatment of preeclampsia. А randomized controlled studyof the effect proposed treatment (intravenous solution of pentoxifylline; solution containing arginine hydrochloride and levocarnitine;rheosorbilact) of 37 pregnant women at 35–40 weeks of gestation with FPD on the background of moderate preeclampsia, wasperformed. Such ultrasound doppler measurements have been studied: systolic-diastolic ratio, resistance index, pulsation index inthe umbilical arteries, right and left uterine arteries, fetal middle cerebral artery, fetal internal carotid artery and fetal aorta before andafter the performed treatment. Statistics were processed using LibreOffice Calc (Mozilla Public License v 2.0), adapted for medicaland biological research. We used nonparametric Wilcoxon criteria, Mann-Whitney criteria at a significance level of p <0.05. After theperformed treatment, stabilization of the fetoplacental blood circulation in women of the main group was observed, which manifestedby decrease in S/D in umbilical artery in 1.3 times, in the left uterine artery in 1.4 times and in the fetal aorta in 1,1 times, and decreasein RI indices in the umbilical artery in 1.1 times, in the right uterine artery in 1.3 times, and increase in the middle cerebral artery in 1.4 times. So, in the course of the proposed treatment, the restoration of the blood flow velocity and the stabilization of vascular resistancein uterine arteries and the umbilical artery were observed in the women of the main group. The research of the possibility of using theabove methodology in earlier gestational age and in the risk group for the prevention of preeclampsia is prospective and requiresfurther attention.
