Abstract:
According to WHO, now on the planet 46 % of women are over the age of 45 years,among women in Ukraine - this is almost half (13.2 million). Of these, 46-68 % sufferfrom climacteric syndrome. An increase in the duration of a healthy life and prolongationof the age of working capacity acquire not only medical, but also socio-economicsignificance, both in Ukraine and in other European countries. Therefore, the aim of thestudy was a comprehensive (involving pituitary, ovarian, adrenal and thyroid hormones)hormonal examination of women of peri- and postmenopausal age with menopausesyndrome to identify the most likely hormonal predictors of this pathology. For thispurpose, 64 women of perimenopausal and postmenopausal age with menopause and42 healthy women of the same age categories had a study of the concentration ofpituitary (LH, FSH, prolactin), ovarian hormones (estradiol, progesterone, testosterone),thyroid hormones (TSH, triiodothyronine (T3), thyroxine (T4)) and adrenal glands (DHEA-s, cortisol) in blood plasma. Hormones were determined using a set of test systemsfrom "Immunotech" (Czech Republic-France) using the radio-immune method.Comparisons of the quantitative data of the two related groups (before and after treatment)were made using Wilcoxon signed rank test. When differences were detected, pairwisegroup comparisons were performed using the Mann-Whitney test. In women ofperimenopausal and postmenopausal age with menopause syndrome, compared withhealthy women of the same age groups, a significant increase in gonadotropin levels(LH by 3.7 and 3.0 times, respectively; FSH by 1.6 and 1.9 times) and a decreaseindicator of prolactin in 1.5 and 1.2 times; estradiol 1.2 and 2.2 times and testosterone2.9 and 2.4 times. A significant decrease in progesterone by 1.9 times occurred only inthe group of postmenopausal women with menopause syndrome. In women ofperimenopausal and postmenopausal age of the main group, a significant decreasewas found in comparison with the control of DHEA-s levels by 1.3 times and 2.2 times,respectively; cortisol 1.2 and 2.0 times; TSH is 2.6 times and 2.0 times, respectively,however, thyroxine tended to increase (the probability p<0.05 was valid only for womenof perimenopausal age). Thus, in postmenopausal women with menopausal syndrome,hormonal imbalance is more pronounced, indicating a deep atrophy of hormone-dependent tissue receptors and, as a result, a deepening of involutive processes.
