Experimental evaluation of changes in mucosal superoxide dismutase after local PRP injection in rats with gastric ulcers and hemorrhagic shock

Abstract

The aim of the study was to evaluate changes in mucosal Superoxide Dismutase (SOD) after local PRP injection in rats with gastric ulcers and hemorrhagic shock in experiment. Methods: The study was performed on 91 Wistar rats (average weight of animals was 183 ± 16 g) according to local and international rules for working with experimental animals. We randomly divide all animals in 5 groups: Control Group (n = 7) – intact animals; Comparison Group (n = 21) – gastric ulcer; Group 1 (n = 21) – gastric ulcer + hemorrhagic shock; Group 2 (n = 21) – gastric ulcer + hemorrhagic shock + local injection of 0.1 ml of 0,9% sodium chloride; Group 3 (n = 21) – gastric ulcer + hemorrhagic shock + local injection of 0.1 ml platelet-rich plasma (PRP).