Abstract:
Acute bacterial meningitis (ABM) leads to a significant number of complications and high mortality.
The aim — to analyze the etiological structure, epidemiological, socio-demographic features and complications in ABM in children of Khmelnitskyi region during 2004–2018.
Materials and methods. The analysis of 346 cases of ABM, of which 217 boys and 129 girls was conducted. The etiology of meningitis
was determined by bacterioscopy, bacteriological sowing, latex agglutination and polymerase chain reaction. Complications were revealed
analytical method, t-criterion and constructing 95% confidence interval.
Results. The disease started with fever 346 (100%), neck stiffness 289 (83.5%) and vomiting 273 (78.9%), less common, alteration
of consciousness 28 (8.1%) and seizures 9 (2.6%). The high level of the cytosis were observed in meningococcal (5801.3±4856.7 cells/
mm3) and Hib meningitis (5152.6±4153.1 cells/mm3), the lowest level was in pneumococcal meningitis (2601.0±1839.6 cells/mm3). The
highest level of liquor protein was in pneumococcal meningitis (179.0±51.0 mg/dl), and the lowest level was in meningococcal meningitis
(102.0±49.0 mg/dl) and Hib meningitis (112.0±56.0 mg/dl). The etiological factor was established in 121 (35.0%) of patients. 52 (15.4%)
of patients had neurological complications.
Conclusions. The majority (58.1%) of ABM are in children under the age of 3. The main causative agent remains N. meningitidis — 57.9%,
the second place is S. pneumoniae — 21.5%, the third Hib — 9.9% of cases. Frequent complications were brain edema 32 (61.5%), seizures
19 (36.5%) and hydrocephalus 8 (15.4%).
The study was conducted in accordance with the principles of the Declaration of Helsinki. The research protocol was approved by the Local
Ethics Committee of the institution mentioned in the work. Informed consent of the children’s parents was obtained for the research.
