Abstract:
In recent years, in chronopharmacology, daily monitoring of biorhythms has become increasingly important as much more informative and clinically relevant. Antral - as a hepatoprotective agent has been successfully used in the clinical practice of Ukrainian doctors for more than 10 years, and as a drug registered in Ukraine since 1994. Evaluation of the circadianian dependence of the severity of hepatoprotective activity of antral on the background of acute toxic hepatitis simulated in four different periods of the day was performed in the third stage of experimental studies. Analysis of circadian rhythms based on the values of the studied indicators in the morning, day, evening, and night periods allows to objectively assess the state of circadian rhythms, and the choice of 09.00, 15.00, 21.00, and 03.00 hours for the study is based on average hours in the morning, day, evening and night, respectively. In general, according to the above analysis of preclinical chronopharmacological study of circadianian features of realization of hepatoprotective properties of antral on the model of acute toxic hepatitis, which was reproduced in four different periods of the day, the most pronounced effect of the drug when taken in the morning and evening.
