Abstract:
Annotation. The development of prognostic criteria for the effectiveness of proton pump inhibitors (PPIs) in the conditions of increasing resistance of Helicobacter pylori to antibiotics is relevant. We studied results of express gastro-pH monitoring (before the start of treatment and on the 5-7th day of PPI administration). We analyzed the results of topographic express pH-metry for 2003-2015 in 157 patients with acid-dependent diseases associated with Нelicobacter pylori. Statistical calculations were performed using MedCalc®Software bvba. In the statistical processing of the results, we used the arithmetic mean and its standard, the probability of the difference was determined by the Student's t-test; Spearman's rank correlation coefficient was determined; ROC curve analysis was performed. We established a correlation between the level of HCl basal secretion before the treatment start and the effectiveness of the PPIs acid-blocking action for the successful Н.р. eradication according to the following indicators of topographic express pH-metry: min pH – 0.21, X pH – 0.22, Mo pH – 0.35 and Me pH – 0.37. At the same time, for max pH, such a relationship was absent (p>0.05) and the Spearman rank coefficient was 0.05, respectively express gastro-pH monitoring before the start of PPIs can be used to predict the effective acid-blocking action of PPI. Express-gastro-pH-monitoring can be used as a screening technique for predicting the effectiveness of successful Helicobacter pylori eradication.
