Abstract:
Healthcare-associated infections (HCAIs) are among the most prominent
medical problems worldwide. In the context of increasing antibiotic resistance
globally, the use of antiseptics as the main active agent and potentiator
of antibiotics for the treatment of purulent-inflammatory complications of
traumatic wounds, burns, and surgical wounds can be considered to tackle
opportunistic infections and their prevention during war. This study presents
a comparative investigation of the antimicrobial efficacy of antiseptics used
for surgical antisepsis and antiseptic treatment of skin, mucous membranes,
and wounds against multidrug-resistant clinical isolates of Acinetobacter
baumannii as a wound pathogen of critical priority (according to the
WHO). It was found that strains of A. baumannii, which have natural
and acquired resistance to antimicrobial drugs, remain susceptible to
modern antiseptics. Antiseptic drugs based on decamethoxine, chlorhexidine,
octenidine, polyhexanide, and povidone-iodine 10% and 2% provide effective
bactericidal activity against A. baumannii within the working concentrations of
these drugs. Chlorhexidine and decamethoxine can inhibit biofilm formation
by A. baumannii cells. In terms of bactericidal properties and biofilm formation
inhibition, chlorhexidine and decamethoxine are the most effective of all
tested antiseptics.
