Abstract:
The aimwas to study the antimicrobial activity of new biomaterials based on decamethoxine and commercially available wound dressings against reference and clinical strains of S.aureus and E.coli. Materials and methods.Developed biomaterials with 0.05 % decamethoxine (DCM No. 1-3) and wound dress-ings containing antiseptics Suprasorb®, SILVERCEL®, Urgotul SSD®, GUANPOLISEPT®, Bétadine® were used for the study. Antimicrobial properties were studied by zone of inhibition (ZOI) testing using the Kirby-Bauer method. Results. In relation to S.aureus ATCC 25923, a significantly higher antimicrobial activity of biomaterials with DCM compared to silver-and iodine-containing wound dressings was found to be 1.97-2.11 (p <0.001) and 1.73-1.86 times (p <0.001), respectively. Similar activity against S.aureus ATCC 25923 was possessed by all three samples with DCM (ZOI -from 21.98±0.18 to 23.58±0.26 mm) and Suprasorb® (19.31±0.17 mm), Guan-polisept® (19.13±0.12 mm). Such a tendency was also found in relation to clinical strains of staphylococci. A high level of activity against E.coli ATCC 25922 was shown by biomaterials No. 1-3 DCM (ZOI –from 19.01±0.33 to 21.54±0.23 mm), Guanpolisept® (18.74±0.12 mm) and Suprasorb® (18.43±0.13 mm). Clinical strains of E.coli showed greater tolerance to antimicrobial biomaterials: the difference in mean values between the ZOI of the reference and ZOI of clinical strains of E.coli was significant for all biomaterials (p <0.001). The most effective were biomaterials with DCM No. 1-3 (ZOI –from 15.58±0.25 to 16.41±0.16 mm), as well as Su-prasorb® (15.82±0.31 mm). Conclusions.Biomaterials based on decamethoxine No. 1, No. 2, No. 3, Suprasorb®, Guanpolisept®, and Béta-dine® have the highest antistaphylococcal activity. Biomaterials with decamethoxin No.1-3, Suprasorb® and Guanpolisept® show the strongest effect on reference and clinical strains of E.coli
