Abstract:
Transformation of uterine spiral arteries (SAs) is critical for healthy human pregnancy. Endothelial damage and dysfunction are common features of all of the pathological features of pre-eclampsia, stimulating the activation of platelets, neutrophils and the coagulation system, and promoting further vascular damage. 58 specimens of the placental tissues were obtained at 6-9 weeks of physiological pregnancy and pregnancy with gestational endotheliopathy. There were investigated morphological parameters that were reflected the processes of optimal transformation of SAs during the first trimester. It was found that pregnancy with gestational endotheliopathy was accompanied by the significant decrease of the intravascular cytotrophoblast invasion, decrease in the formation of cytotrophoblast plugs, accompanied by a slight expansion of lumen SA.
