Abstract:
Objective: To assess the outcomes of treatment the couples with infertility or recurrent
miscarriage with restorative reproductive approach and to identify predictors of success. Methods: It
was a retrospective study of 282 married couples, who were included in the program in 2 outpatient
gynaecological centers in May 2010 - December 2014. The couples were observed to the end of
pregnancy (or pregnancies) or withdrawal from the program. All the couples were taught to track the
cycle with the Creighton Model FertilityCare System or the sympto-thermal method, and almost all
received additional medical treatment. The main outcome was live birth, the secondary outcomes
included conceptions, unsuccessful pregnancies, low birth weight and prematurity. Results: In life-
table analysis, the adjusted cumulative proportion of first conceptions for those completing up to 24
months of NPT treatment was 77,7% (crude proportion 47.9%). The adjusted cumulative proportion of
live births (included only women whose first pregnancy in the program was successful) was 73.6%
(117 births, crude proportion 41.5%). The crude proportion of first live births (124 births, including
7 live births in women whose first pregnancy result was miscarriage) was 44%. Mean time to
achieving pregnancy was 8 months (from 1 to 44 month). All the births except one were singleton.
There were only 3 preterm births (gestational age less than 36 weeks) with one of them in the
mentioned twin pregnancy. Only the babies of these 3 pregnancies were born with weight less than
2500 g.
The favorable predictors of live birth were younger age, shorter time of trying for baby, good
compliance, pregnancy in history. The unfavorable were hyperprolactinemia, uterine fibroids,
endometriosis, male factor. Conclusion: The outcomes of restorative reproductive treatment the
couples with infertility or recurrent miscarriage
