Гепатопротекторна роль рослинних препаратів Закарпаття при експериментальних атеросклерозі та цукровому діабеті 2-го типу

Abstract

Метою роботи стало вивчення структурної перебудови печінки при одночасному моделюванні атеросклерозу і цукрового діабету 2-го типу та гепатопротекторної дії традиційних лікарських рослин Закарпаття на рівні доказової медицини. Background. Today atherosclerosis and type 2 diabetes mellitus are the most socially significant diseases. The situation is aggravated by chronic stress experienced by the Ukrainian people. There is a liver among target organs which are affected primarily. Objective. We studied the structural reconstruction of the liver tissue during the experimental atherosclerosis and diabetes mellitus and at its prophylaxis with herbal preparations. Materials and methods. The study was performed on 50 male rats. We used the classical model of atherosclerosis by N. Anichkov and dexamethasone suppression model of diabetes mellitus. We used a decoction of the Zakarpattia medicinal plants (by our recipe) as a prophylactic agent. Results. Experimental model of atherosclerosis and diabetes mellitus showed that degenerative changes had been developed in the liver. These changes are the most pronounced in the group with the concurrent simulation of pathologies. Prophylactic administration of traditional medicinal plants of Zakarpattia had pronounced hepatoprotective effect. Conclusions. Experimental atherosclerosis and diabetes mellitus lead to the degenerative changes in the liver parenchyma and stroma. Prophylactic administration of decoction of medicinal plants of Zakarpattia has hepatoprotective effect confirmed by the morphological studies.