Association of FGFR2 (rs2981579) gene polymorphism with the risk of mesial occlusion

dc.contributor.author	Storozhenko, K. V.	en
dc.contributor.author	Shkarupa, V. M.	en
dc.date.accessioned	2018-10-08T16:13:13Z
dc.date.available	2018-10-08T16:13:13Z
dc.date.issued	2017
dc.identifier.citation	Storozhenko K. V. Association of FGFR2 (rs2981579) Gene Polymorphism with the Risk of Mesial Occlusion / K. V. Storozhenko, V. M. Shkarupa // Cytology and genetics. - 2017. - Vol. 51, No. 5. - P. 361-364.	en
dc.identifier.uri	https://dspace.vnmu.edu.ua/123456789/3079
dc.description.abstract	The molecular-genetic testing of the polymorphic rs2981579 (C>T) locus of the FGFR2 gene as the marker of increased predisposition to the development of mesial occlusion was carried out in 110 patients with mesial occlusion and 103 general-population control subjects from Ukraine. It was shown that polymorphism rs2981579 in gene FGFR2 is associated with mesial occlusion (OR = 1.67, 95% CI = 1.14–2.45, p = 0.009). Compared to CC carriers, TT+CT carriers had a 3.21-fold higher risk of mesial occlusion (95% CI = 1.57–6.57, p = 0.001). We found the protective effect of the homozygous allele C on mesial occlusion development (OR = 0.31, p = 0.001). This is the first published data on FGFR2 polymorphisms rs2981579 (C>T) in patients with mesial occlusion.	en
dc.language.iso	en	en
dc.subject	mesial occlusion	en
dc.subject	gene polymorfism	en
dc.subject	FGFR2	en
dc.title	Association of FGFR2 (rs2981579) gene polymorphism with the risk of mesial occlusion	en
dc.type	Article	en