ASSOCIATION OF PLASMA GALECTIN-3 CONCENTRATION IN STAGE II HYPERTENSIVE DISEASE PATIENTS WITH INSTRUMENTAL TEST INDICATORS

Abstract

The article is intended to find associations of plasma galectin-3 concentration of stage II hypertensive disease (HD) patients with some instrumental test readings. Plasma galectin-3 concentration was found ranging from 0.38 to 5.37 (mean 2.54±1.12 ng/ml) in the total cohort of patients (n =120). The median was 2.47 (rounded to 2.5) with the interquartile range of 1.67 and 3.27 ng/ml. To identify homogeneous groups with relatively small (RLL) and relatively large galectin- 3 plasma concentration (RHL), we used the rounded median value of the indicator. RLL and RHL of the total cohort were ≤ 2.5 and - > 2.5 ng/ml, respectively. It was found that plasma galectin-3 RHL (> 2.5 ng/ml ) was associated with a significantly lower circadian index and elevated electrical instability of the myocardium, which was manifested by an increase of both supraventricular and ventricular arrhythmogenesis (significantly more cases of supraventricular extrasystole (SVE) and frequent ventricular extrasystole (VE), as well as cases of paired and group VE). No association was found between galectin-3 plasma level and echocardiography (EchoCG) readings, structural and functional state of the myocardium, types of left ventricle (LV) structural and geometric remodeling. It was demonstrated that RHL was associated with an increase of aortic valve (AV) calcification incidence.