Abstract:
The article is intended to find associations of plasma galectin-3 concentration of stage
II hypertensive disease (HD) patients with some instrumental test readings. Plasma galectin-3
concentration was found ranging from 0.38 to 5.37 (mean 2.54±1.12 ng/ml) in the total cohort of
patients (n =120). The median was 2.47 (rounded to 2.5) with the interquartile range of 1.67 and
3.27 ng/ml. To identify homogeneous groups with relatively small (RLL) and relatively large galectin-
3 plasma concentration (RHL), we used the rounded median value of the indicator. RLL and RHL of
the total cohort were ≤ 2.5 and - > 2.5 ng/ml, respectively. It was found that plasma galectin-3 RHL
(> 2.5 ng/ml ) was associated with a significantly lower circadian index and elevated electrical
instability of the myocardium, which was manifested by an increase of both supraventricular and
ventricular arrhythmogenesis (significantly more cases of supraventricular extrasystole (SVE) and
frequent ventricular extrasystole (VE), as well as cases of paired and group VE). No association was
found between galectin-3 plasma level and echocardiography (EchoCG) readings, structural and
functional state of the myocardium, types of left ventricle (LV) structural and geometric remodeling.
It was demonstrated that RHL was associated with an increase of aortic valve (AV) calcification
incidence.
