Abstract:
Objectives: In early human pregnancy placental trophoblasts migrate along uterine spiral arteries (SAs) and remodel these vessels into wide-bore conduits in a process essential for successful pregnancy. This work examined the consequences of the preclinical and manifest forms of gestational endotheliopathy (GE) on the adequacy conversion of the SAs and the main characteristics of the trophoblast migration.
Study design: 58 specimens of the placental tissues were obtained at 6-9 weeks of physiological pregnancy and pregnancy with gestational endotheliopathy. There were investigated histometrical and morphometrical parameters that were reflected the processes of optimal transformation of SAs during the first trimester.
Results: It was found that pregnancy with gestational endotheliopathy was accompanied by the significant decrease of the values of perimeter, cross-sectional area, and lumen in the SAs. In addition, we obtained reduction of intensity of the vascular invasion internally cytotrophoblast and depression of the interstitial trophoblast invasion in GE, also.
Conclusion: Abnormal transformations of the SAs was more common in specimens of the placental tissues from women with GE.
