Study of the effect of Saponaria officinalis herb extract on histological changes in the marginal vein of the ear under conditions of experimental thrombophlebitis

Abstract

Thrombophlebitis is recognized as one of the most common complications of chronic venous insufficiency (CVI). Its course is characterized by inflammation of the venous wall and the formation of blood clots in the lower extremities of varicose veins. Thrombophlebitis is diagnosed according to various data in 5-60 % of patients with CVI. The number of drugs with a phleboprotective effect and the ability to reduce the processes of thrombus formation in veins on the pharmaceutical market of Ukraine and the world is extremely limited. As a promising object, as a new phleboprotective drug, medicinal plant raw materials can be considered, namely the extract of the herb Saponaria officinalis, for which venotonic and antiexudative effects have been established in previous studies. The aim of this work was to study the effect of Saponaria officinalis herb extract on changes in the histological parameters of the ear vein in rabbits under conditions of experimental thrombophlebitis.