Fluticasone furoate and vilanterol and survival in chronic obstructive pulmonary disease with heightened cardiovascular risk (SUMMIT): a double - blind randomised controlled trial
Vestbo, J.; Anderson, J. A.; Brook, R. D.; Calverley, P. M. A.; Celli, B. R.; Crim, C.; Martinez, F.; Yates, J.; Newby, D. E.; Abrahamovych, O.; Amer, L.; Berenfus, V.; Biloglazov, V.; Bilokonna, N.; Blazhko, V.; Borovyk, V.; Boyko, M.; Butvyn, S.; Chopey, I.; Dudchenko, L.; Dziublyk, O.; Feshchenko, Y.; Fushtey, I.; Gavrysyuk, V.; Godlevska, O.; Golovchenko, N.; Golovchenko, O.; Grishyna, O.; Gyrina, O.; Hospodarskyy, I.; Iabluchanskyi, M.; Iashyna, L.; Kaidashev, I.; Kazymyrko, V.; Khomazyuk, T.; Khvelos, S.; Knopyk, L.; Kopytsya, M.; Korzhevnyk, I.; Koshukova, G.; Kovalchuk, T.; Krakhmalova, O.; Krasnokutskiy, S.; Krasyuk, S.; Kulyk, A.; Kulynych, O.; Kuryata, O.; Levchenko, O.; Monogarova, N.; Mostovoy, Y.; Nalotov, S.; Ospanova, T.; Ostrovskyy, M.; Panina, S.; Pasiyeshvili, L.; Pavlyk, S.; Pertseva, T.; Plesh, I.; Prystupa, L.; Rodionova, V.; Romaniuk, I.; Shvets, N.; Skrypnyk, I.; Stanislavchuk, M.; Stets, R.; Synenko, V.; Syvolap, V.; Teliatnikova, Z.; Tovt-Korshynska, M.; Vatutin, M.; Vayda, M.; Vishnivetsky, I.; Vizir, V.; Voloshyna, O.; Vynnychenko, L.; Yagensky, A.; Yatsyshyn, R.; Zharinova, V.; Zhebel, V.
Date:
2016
Abstract:
Chronic obstructive pulmonary disease (COPD) often coexists with cardiovascular disease. Treatments for airflow limitation might improve survival and both respiratory and cardiovascular outcomes. The aim of this study was to assess whether inhaled treatment with a combined treatment of the corticosteroid, fluticasone furoate, and the long-acting β agonist, vilanterol could improve survival compared with placebo in patients with moderate COPD and heightened cardiovascular risk.
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