Порівняльна оцінка антиапоптотичної та антинейрогліопроліферативної активності у мелатоніну та цитиколіну на клітини сітківки при контузійній травмі ока за даними протокової цитометрії

Abstract

In article, using flow cytometry, a comparative evaluation of the effect of melatonin and citicoline on the course of apoptotic processes in rabbit’s retinal cells under experimental eye contusion with fragmentary nuclear DNA was performed. At the same time, the aim was to detect their possible anti-neuroglioproliferative activity. It was established that melatonin by intravenous infusion in a therapeutically effective dose 10 mg/kg on average had a 1,55 higher anti-apoptotic effect (p<0,05) than citicoline, administered in dose 250 mg/kg, calculated based on the number of cells in the retina of nuclear DNA that had signs of fragmentation. Similar treatment of rabbit’s eye contusion prevented neuroglial proliferation, which was reflected in a fairly smaller number of cells whose DNA was in the replication phase, with a predominance of melatonin over citicoline by an average of 1.55 times, p<0.05.