Аннотации:
Conclusions. Vitamin D deficiency and hyperhomocysteinemia cause a significant amount of metabolic abnormalities in the body, which is a possible cause of a number of diseases of the oral cavity. Probably the effect of changes in the status of vitamin D on dental pathology is mainly due to a violation of phosphorous-calcium metabolism, including genetic origin, as well as inhibition of immune processes. Influence of hyperhomocysteinemia on the pathogenesis of oral cavity diseases can be related to the dysregulation of genetic processes, oxidative stress, osteoporosis, and endothelial dysfunction characteristic of this condition. In general, the importance of both factors–vitamin D deficiency and especially hyperhomocysteinemia in the pathology of individual organs of the oral cavity, nosological forms and related mechanisms–is insufficiently covered in the literature. There is no data on participation in the pathogenesis of dental diseases at the same time, both of these factors are absent at all. Thus, there is a need for further research in this direction with the use of modern biochemical, biophysical, morphological, molecularly-genetic and clinical-epidemiological studies, the implementation of which will contribute to the provision of dental human health.
