Association of alleles and genotypes by polymorphic marker rs1805010 lle50Val of the IL4RA gene with the development of atopic bronchial asthma in school-age children, depending on the sex and type of inheritance

Abstract

Genetic and population-statistical results of association of alleles and genotypes of rs1805010 lle50Val polymorphism of IL4RA gene are analyzed,in 75 patients with atopic bronchial asthma and 25 healthy children, depending on the article, type of inheritance, homozygous or heterozygous genotype. The results of the study showed that in general the increased risk of developing allergic asthma in children is determined in carriers of homozygous genotype A/A polymorphism rs1805010 lle50Val gene IL4RA, because in patients with asthma, it occurs 4.34 times more often than in almost healthy children (OR = 6.10; 95% CI [1.33-27.93]; p <0.003),than in almost healthy children. The association of the lle50Val polymorphism of the IL4RA gene in rs1805010 with the development of bronchial asthma by us among girls has not been established,, while the homozygous genotype G / G is more common (0.368) among boys who have, accordingly, a reduced risk of developing bronchial asthma (OR = 0.34; 95% CI [0.16-0.73]; p = 0.003)