Abstract:
The purpose of the work is to analyze contemporary views on the morphological changes of lung tissue in inflammatory disease in the clinical and experimental conditions and results of correction by using the antioxidants. The analysis is based in a review if foreign articles for 2014-2019, using the scientometric databases PubMed, Web of Science and Google Scholar. According to the latest data from WHO and WORLD HEALTH RANKINGS 5-year mortality rate of such disease as COPD typically ranges from 40% to 70%, depending on disease severity, while the 2-year mortality rate for people with severe COPD is about 50%. We know that almost 90% of COPD deaths occur in low- and middle-income countries such as Ukraine. Thereby mortality rate from lung tissue diseases in Ukraine is 11.11%. These diseases often accompanied by inflammation and oxidative stress. The last can cause mitochondrial dysfunction, dynamic changes and mitophagy impairment, which leads to increase the number of superoxide anions, hydrogen peroxide etc., inflammatory responses and cellular senescence. They all play important roles in the pathogenesis of chronic lung diseases, such as chronic obstructive pulmonary disease, pulmonary fibrosis and bronchopulmonary dysplasia. Many studies in vitro approved the role of antioxidants in the decreasing of the degree of morphological changes: inflammatory cells infiltration and alveolar edema, permeability and inflammation. In vivo disease development is mainly related to the many conditions, but closely to its severity and possible of combination with other diseases. Thereby treatment of such diseases by using e.g. leaves extract of different herbs can be prescribe to ameliorate the level of reactive oxygen species and decrease the possible cell injure made by anti inflammatory medicines.
