Abstract:
Introduction: Burn injuries are one of the most common traumatic injuries in the world. The leading cause of burn patients‘ death is infection (76.3 %).
Aim: To establish the analytical pattern of sensitivity to antibiotics of infectious agents that predominate in patients with severe burns during treatment in the burn center of a tertiary care facility.
Materials and methods: We´ve established the analytical pattern of sensitivity to antibiotics of microorganisms (A. baumannii, P. aeruginosa, n = 1227) predominating in patients (n = 624) with severe burns (IIb – III degree, burn area 30.0–85.0 % of body surface) during treatment in the burn center of a tertiary care facility in 2015 – 2020. Statistical processing of research results was performed using standard programs “Microsoft Excel 2010”, “Statistica 12.0”.
Results: P. aeruginosa have the highest incidence at 2 weeks of treatment with a gradual decrease over 3 – 4 weeks. According to Shapiro – Wilk´s W test (= 0.96; p > 0.05) – the amount of P. aeruginosa isolated from patients with severe burns over the years of research is distributed according to the normal law.
A. baumannii have the highest incidence in the period of hospitalization and 1 week of treatment with a gradual decrease at 2 – 4 weeks. According to the Chi-square test (= 0.91; p > 0.05), the number of A. baumannii is distributed exponentially. Multidimensional statistical analysis of hierarchical clustering method allowed to establish the distribution of antibiotics in clusters according to the degree of A. baumannii, P. aeruginosa sensitivity to them.
Conclusions: P. aeruginosa showed the greatest sensitivity to imipenem, meropenem, amikacin, were least sensitive to amoxicillin-clavulanate, aztreonam, pefloxacin, norfloxacin. A. baumannii were the most sensitive to polymyxin, cefoperazone-sulbactam, doxycycline, tobramycin, ampicillin-sulbactam (Fig. 6, Ref. 28). Text in PDF www.lekarskyobzor.sk.
