Abstract:
The results of experimental studies on the impact angiotensin inhibitor converting enzyme - lisinopril on the processes of reparative regeneration of liver tissue of rats with chronic toxic hepatitis were present. The aim: to investigate the effect of lisinopril on phases of the cell cycle ploidy and nuclear DNA of liver cells of rats model of chronic toxic hepatitis (CTH) in rats.
Experimental studies conducted on 34 white laboratory immature rats with an initial body weight 50-70 gr. CTH was modelling by intragastric administration of 0,1 ml/100 g weight CCl4 oil solution twice a week in combination with a 5% solution of ethanol for six weeks. Lisinopril (at a dose of 20 mg/kg) was introduced into the stomach simultaneously with hepatotoxins daily for six weeks.
Conclusion. Administration of lisinopril with hepatotoxins promotes the process of reparative regeneration of liver tissue due to the hyperplasia of hepatocytes, as indicated by the increase of the percentage of hepatocytes with diploid set of DNA reduction of polypoid nuclei amount and restoration of the proportion of nuclei in the range of G0-G1.
