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Відображені елементи 1-20 з 147

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3D chitin scaffolds of marine demosponge origin for biomimetic mollusk hemolymph-associated biomineralization ex-vivo.

Wysokowski, M.,; Petrenko, I.,; Kovalchuk, V.,; et al. (Marine Drugs, 2020)

Structure-based tissue engineering requires large-scale 3D cell/tissue manufacture technologies, to produce biologically active scaffolds. Special attention is currently paid to naturally pre-designed scaffolds found in ...
Addition of Dexamethasone to local wound infiltration analgesia in diabetic foot surgery

Дмитрієв, Д. В.; Назарчук, О. А.; Бабіна, Ю. М. (2021)

Pain following diabetic foot surgery is significant, and effective analgesia is associated with an improvement in functional outcomes. Dexamethasone may facilitate the action of local an esthesia, but its role as an ...
Adjunctive inhaled amikacin in infants with ventilator-associated pneumonia optimizes the complex antimicrobial therapy: pilot study

Levchenko, B.; Nazarchuk, О.; Dmytriiev, D.; Bahniuk, N.; Melnychenko, M.; Dmytriiev, K. (Acta Biomed, 2023)

Background and aim: VAP remains the second leading cause of death among the patients with noso-comial infections and its incidence varies significantly from 5% to 60% reaching on average 10%. It is of crucial importance ...
AID/APOBEC зависимый соматический гипермутагенез и перестройки ДНК иммуноглобулиновых и неиммуноглобулиновых генов

Колотова, Т. Ю.,; Макаренко, В.Д.,; Сорокоумова, Л.К.; Давиденко, М. Б. (Annals of Mechnikov Institute, 2019)

Редактирование индуцируемой активацией дезаминазой (AID) ДНК лежит в основе соматического гипермутагенеза Ig генов, создающего разнообразие антител, и рекомбинации переключения классов Ig. Действие дезаминаз AID/APOBEC ...
Antimicrobial activity assessment of food preservatives containing organic carboxylic acids

Fomina, N. S.; Kovalchuk, V. P.; Vovk, I. M.; Fomin, O. O.; Kovalenko, I. M. (Клінічна та профілактична медицина, 2024)

Microbial spoilage of food products has been a perennial problem. According to the WHO, the world records between 68.4 to 275 million cases of acute infectious diarrhea annually. The microbiological safety of food products ...
Antimicrobial activity of antiseptics in the prevention ofpostoperative infectious complications

Bagnyuk, N. A.; Nazarchuk, О. А.; Babina, Y. M.; Chornopyshchuk, R. M.; Kulyk, A. V. (Biomedical and Biosocial Anthropology, 2021)

Recently, among hospital strains of microorganisms, an increase in the number ofantiseptic-resistant strains of opportunistic pathogens has been registered, whichsignificantly affects the effectiveness of these drugs. It ...
Biofilm forming activity of non-fermenting gram-negative bacteria

Kovalchuk, V. P; Nazarchuk, O. A; Burkot, V. M.; Fomina, N. S.; Prokopchuk, Z. M.; Dobrovanov, O. (Wiadomosci lekarskie, 2021)

To study the influence of chemical, physical factors on the biofilm forming activity of P. aeruginosa, A. baumannii. Materials and methods: Biofilm forming activity of P. aeruginosa (10 isolates) and A. baumannii (10 ...
The chitinous skeleton of Ianthella basta marine demosponge as a renewable scaffold-based carrier of antiseptics

Dziedzic, I.; Dydek, K.; Voronkina, A.; Kovalchuk, V.; Jesionowski, T.; Ehrlich, H. (Polysaccharides, 2024)

The chitinous skeleton of the marine demosponge Ianthella basta exhibits a unique networklike 3D architecture, excellent capillary properties, and chemical inertness, making it highly suitable for interdisciplinary research, ...
Cluster analysis allowed to identify antifungal drugs that retain efficacy against Candida albicans isolated from patients with inflammatory diseases of the soft tissues of the maxillofacial area

Faustova, M.; Dobrovolskyi, O.; Loban, G.; Bereza, Y.; Kotelnikova, A.; Dobrovolsky, V. (Frontiers in Oral Health, 2024)

Physicians are increasingly prescribing antifungal drugs empirically to treat hospital-acquired infections quickly. This makes it obvious that fungal infections require more attention and systematic monitoring of resistance ...
Cluster analysis revealed antibiotics with the highest efficacy against bacteria isolated from patients with infectious and inflammatory diseases of the soft tissues of the facial area

Faustova, M.; Nazarchuk, O.; Loban, H.; Ananieva, M.; Chumak, Y.; Lokes, V.; Bereza, Y.; Avetikov, D.; Vidiscak, M. (Lekarsky Obzor, 2024)

Background: Incorrect prescription of antibiotics in dental surgery leads to the acquisition of antibiotic resistance of microorganisms. Aim: The aim of the given study was to conduct a retrospective cluster analysis of ...
Comparative study of antimicrobial properties of biomaterials and dressings based on antiseptics against gram-negative bacteria as pathogens of wound infections

Denysko, Т. V (Bulletin of Problems Biology and Medicine, 2024)

Introduction. The emergence of multiple drug resistance in bacteria has become one of the most terrible challenges of this century: the prevalence of infections that are difficult to treat is increasing, and there are no ...
Correlation of susceptibility to antiseptics with biofilm-forming properties in acinetobacter baumannii as a pathogen of surgical infection

Nahaichuk, V.; Nazarchuk, O.,; Faustova, M.,; Ananieva, M.,; Turzhanska, O. (Malaysian Journal of Medicine and Health Sciences, 2020)

Introduction: The purpose of this research was to study the biofilm-forming properties of clinical strains of A.baumannii, isolated from burn wounds in patients of ICU, and their sensitivity to antiseptics. Methods: 220 ...
Determination of CCL2 / MCP-1 levels in the serum of children with melanocytic nevus in the postoperative period after using different methods of surgical treatment

Pasichnyk, O.; Konoplitskyi, V.; Korobko, Yu.; Nazarchuk, O.; Dmyrtriiev, D.; Babina, Yu. (Acta Biomed, 2022)

To date, there are many methods and ways to remove pigmented skin tumors, which have their own indications and contraindications for use, early or late complications. The aim of the study was to determine the level of CCL2 ...
Diagnostic significance of Toll-like receptors 4 in critical patients with infectious complications of the respiratory organs

Dmytriiev, D. V.; Nazarchuk, О. А.; Melnychenko, M. V.; Levchenko, B.I.; Bahniuk, N. A. (2021)

n. Ventilator-associated respiratory infection (VARI) is a common hospital complication in the intensive care unit (ICU) associated with medical care [1]. Among which there are known ventilator-associated tracheobronchitis ...
Dynamics of changes in quality of life and local levels of TNF-α and IL-1β in patients with acute viral rhinitis

Grebeniuk, D.; Hrytsun, Y.; Nazarchuk, H.; Mashevska, O.; Levytska, L.; Chepel, L.; Melnychenko, M.; Pallii, I.; Bobyr, V. (Journal of Pharmaceutical Research International, 2021)

Bacterial vaginosis is among serious health problem for women of reproductive age commonly associated with aberrant changes in the vaginal microbiome that influences on their local changes in inflammatory mediators and ...
Effect of microampere current on clinical strains of acinetobacter baumannii with multiple drug resistance and the manifestation of the bioelectric effect

Nazarchuk, О. А.; Bebyk, V.V.; Denysko, T. V.; Nazarchuk, H. H.; Parkhomenko, O. G. (Вісник проблем біології і медицини, 2025)

There is an urgent need to develop new effective strategies to combat resistant bacteria. The aim was to investigate the effect of microampere current on resistant A. baumannii strains and its impact on bacterial ...
Effectiveness of Perioperative Local Use of Anesthetics and Antiseptics in Patients with Purulent-necrotic Lesions of Lower Extremities in Diabetes Mellitus.

Babina, Y.,; Dmyrtriiev, D.,; Nazarchuk, O.,; Hormash, P.,; Vernyhorodskyi, S (Journal of Pharmaceutical Research International, 2021)

Background: Every second patient with the diabetes mellitus (DM) needs surgery due to purulent-necrotic changes in the feet. The aim of the study was comparative morphological examination of the course of the wound process ...
Efficacy of inhaled antibiotics in infants with ventilator-associated pneumonia

Dmytriiev, D.; Dobrovanov, O.; Nazarchuk, O.; Levchenko, B.; Bahniuk, N. A.; Supinova, M. (Lekarsky Obzor, 2022)

The rise of antibiotic resistance around the world is a very current problem. The combination of increasing resistance to various bacteria and the absence of new types of antibiotics have led to the search for alternative ...
Electrochemical method for isolation of chitinous 3D scaffolds from cultivated Aplysina aerophoba marine demosponge and its biomimetic application

Nowacki, K.,; Stępniak, I.,; Machałowski, T.,; Jesionowski, T.,; Ehrlich, H.,; Kovalchuk, V.,; et al. (Applied Physics A: Materials Science and Processing, 2020)

Three-dimensional (3D) biopolymer-based scaffolds including chitinous matrices have been widely used for tissue engineering , regenerative medicine and other modern interdisciplinary fields including extreme biomimetics. ...
Experimental investigation of the effectiveness of local application of a combination of antiseptic and anesthetic on the model of contaminated wound

Babina, Y. (Вісник Вінницького національного медичного університету, 2023)

A high risk of infections in surgery is associated with microbial contamination with opportunistic microorganisms Staphylococcus aureus. Objective: to study the antimicrobial and analgesic effect of decamethoxine combined ...

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