Structural and functional changes of cardiovascular system in children with asthma

Abstract

To study the cardiovascular system status in schoolchildren depending on the level of bronchial asthma control. The study enrolled 189 children with persistent BA aged 6–17 years and 30 gender- and age-matched apparently healthy individuals who made up a control group. In addition to clinical examinations assessment electrocardiogram monitoring results and markers of myocardial damage as well as electrolytes were studied to assess the cardiovascular system status in children with various levels of BA control. Patients with uncontrolled bronchial asthma commonly have functional cardiovascular disorders, decreased K+ level in blood serum and erythrocytes as well as increase in total CPK, isoenzyme CPK–MB, total lactate dehydrogenase and lactate dehydrogenase isoenzyme 1.