Abstract:
The aim of the work – to investigate the content of galectin 3 in blood plasma in patients with hypertension
stage IIІ and its changes in the presence of comorbid chronic coronary artery disease and frequent ventricular
extrasystole.
Materials and methods. We examined 120 people, including 34 (28.3 %) women and 86 (71.7 %) men, with an aver
age age of 57.3±0.9 years, with hypertension (HD) stage IIІ with/without comorbidity of chronic coronary disease (CHD)
and frequent ventricular extrasystole (VE). All patients undergone echocardiography, Holter monitoring of electrocardio
grams, stress tests and/or coronary ventriculography. Considering the presence or absence of comorbid CHD and fre
quent VE, four groups of patients were identified: 1st (n=30) – patients with HD without concomitant CHD and VE, 2nd
(n=30) – patients with HD and frequent VE, 3rd (n=30) – patients with HD and concomitant CHD, 4th (n=30) – patients with
HD and concomitant CHD and frequent VE. The content of galectin 3 in EDTA blood plasma was determined by immu
noenzymatic method using a commercial kit «Human GAL3 (Galectin 3) ELISA Kit» («Elabscience iotechnology Inc.», USA).
Statistical analysis of the study results was performed using methods of variational statistics with Microsoft Excel (2019) and
Statistica 12.0 (Statsoft, USA).
Results. It was determined that in patients with HD stage IIІ with and without concomitant CHD and frequent VE
(n=120), the mean plasma galectin 3 level was 2.54±1.12 ng/ml (median value – 2.47; interquartile range – 1.67 and
3.27 ng/ml). The rounded median value of the indicator was used to identify uniform groups with relatively low and rela
tively high galectin 3 content (hereinafter referred to as RLC and RHC, respectively). The RLC of galectin 3 for the examined
sample was 2.5 and the RHC was > 2.5 ng/ml, respectively. Significantly higher plasma galectin 3 levels (3.41 ng/mL)
were found in the group with HD and concomitant CHD and VE, and the lowest (1.74 ng/mL) in patients with HD without
concomitant CHD and VE.
Conclusions. Increased plasma galectin 3 concentration is associated with older age and male gender, the presence
of alimentary constitutional obesity, concomitant CHD and frequent VE, and the use of 3 and 4 antihypertensive drugs
compared to 2, and in cases of use of thiazide/thiazide like diuretics, antiplatelet drugs, and statins.
