Placental expression of plasminogen activator inhibitor-1 and tissue- type plasminogen activators in gestational endotheliopathy

Abstract

The fibrinolytic imbalance might have a pivotal role in hypercoagulability seen in gestational endotheliopathy. Our objective was to determine the novel fibrinolytic markers of blood coagulation related factors in placental tissue in preeclamptic and normal pregnancies. 61 specimens of the placental tissues were obtained after delivery at physiological pregnancy, gestational endotheliopathy and preeclampsia. There were investigated placental expressions of plasminogen activator inhibitor-1 (PAI-1) and tissue- type plasminogen activators (t-PA). It was found that preeclampsia was accompanied by the significant decrease of the placental expression of t-PA and increase placental levels of PAI-1.