Regularities of lectinogistochemical differentiation of human thymus gland bud in prenatal ontogenesis

Abstract

In this study of the material taken from 108 human embryos (Em), pre-feti (Pf) and feti (Ft), we have first described the arrangement of glycopolymers and proved the effect of successive redistribution of glycopolymers – the lectin receptors in cells on their surface and in the extracellular tissue structures during organ-specific differentiation of epithelial and mesenchymal human thymus gland buds, and the role of these molecules in epithelial-mesenchymal interaction depending on heterogeneous origin of the buds. We have proved that fibrylogenesis of embryonic connective tissues is associated with expression of receptors and reduction of various lectins (Lc). Organ-specific differentiation of mesenchymal cells in fibroblasts is also accompanied by redistribution of lectin-reactive glycoconjugate. We have studied the seguence of biosynthesis and the activity of polysaccharide complexes, and confirmed their role in the differentiation and structural transformation of thymus gland in prenatal ontogenesis phase.