Короткий опис (реферат):
Bronchiolitis, according to European studies, is the most common viral infection
of the lower respiratory tract, that accounts for 18% of all hospitalized infants. Given
that the eosinophilic cationic protein (ECP) is one of the main proteins found in the
granules of eosinophils, it is important to count it as a marker of allergic
inflammation in bronchiolitis. The aim of the study was to explore and exam the
clinical features and markers of the inflammatory allergic process of bronchiolitis in
infants.
METHODS: A clinical examination of 40 infants who were hospitalized in clinical
pediatric hospital was conducted. Regarding the complex clinical - a laboratory
examination of children was done to determine the levels of ECP and IgE in blood
serum.
RESULTS: In infants with bronchiolitis with a background of an allergic history - the
severity of the disease was manifestoed by a longer course of symptoms and a longer
stay at the hospital clinic. It was found that in infants of the main group, the average
content of ECP (49.15±10.87 ng /mL) in the blood serum was significantly higher
than in children of the comparison group (15.3±2.88 ng /mL), (P<0.05). In most
children in main group (55.6±10.24%) the level of IgE was within the reference
values (19.43±6.17 IU /mL).
CONCLUSIONS: Eosinophilic cationic protein is a laboratory component that can be
used for inflammatory respiratory diseases in children. Elevated ECP levels in serum
were significantly more detected than IgE in children with bronchiolitis. The level of
ECP has a high specificity and sensitivity in infants with bronchiolitis with an allergic
background in their history; however, it requires the support of other allergic
inflammatory markers in children without allergic history.
