Circadian rhythms of endothelial nitric oxide synthase production in females with rheumatoid arthritis and arterial hypertension depending on NOS3 Т786С gene polymorphism

Abstract

One of the most common comorbidity in patients with rheumatoid arthritis (RA) is arterial hypertension (AH), with incidence ranging from 20 to 60%. Mechanisms of this comorbidity arises a lot of interest. In our previous study was established the association of T786C NOS3 (rs2070744) gene polymorphism with AH in females with RA in the Ukrainian population [1]. Objectives: So next, we were aiming to investigate daily fluctuation of endothelial nitric oxide synthase (NOS3) in RA patients with AH depending on NOS3 T786C gene polymorphism