Influence of interval normobaric hypoxytherapy on the processes of ischemic preconditioning in the myocardium of patients with chronic obstructive pulmonary disease

Abstract

The aim: Determination of cardioprotective effect of interval normobaric hypoxia in medical rehabilitation of patients with COPD. Materials and methods: 123 patients with COPD who received basic drug therapy were examined and were divided into 2 groups. Patients of the main group (93 persons) additionally received 2 courses of 20 sessions of interval normobaric hypoxia. All patients underwent echocardiographic examination at the beginning and after 1 year of follow-up. Results: Prior to treatment, all patients had changes in the myocardium of both ventricles, due mainly to hypoxic and inflammatory effects and to a lesser extent to increased pulmonary artery pressure. Interval normobaric hypoxytherapy caused adaptive-adaptive reactions of the cardiovascular system, which manifested a positive effect on the state of both left and right ventricles: increase in stroke volume and expulsion fraction, decrease in E-DV and E-SV of the left and right ventricular E-DS, elimination of myocardium. However, the result is more effective in patients with GOLD 1 and GOLD 2 compared to GOLD 3. Conclusions: The use of interval normobaric hypoxytherapy in the rehabilitation of COPD, initiated by ischemic preconditioning, is pathogenetically justified because it triggers endogenous mechanisms of cardioprotection and metabolic adaptation.