Markers of undifferentiated connective tissue dysplasia in female patients with acute Q-myocardial infarction

Abstract

Myocardial infarction (MI) remains the leading cause of death in patients with coronary heart disease (СHD) worldwide. Over the past twenty years, there has been a tendency to increase the prevalence of congenital disorders of connective tissue. The relevance of this problem is due not only to the growing occurrence of undifferentiated connective tissue dysplasia (UCTD) and a variety of complications but also to medical and social problems resulting from associated somatic diseases. Considering the high social significance of the problem of CHD on the background of UCTD, and because it affects mainly people of working age, this study aimed to investigate stigmas of dysplasia in women with Q-MI on the background of UCTD. The most common stigmas of dysembryogenesis in patients with UCTD were various anomalies of the hands and feet (100%), ophthalmic stigmas and microanomalies of the auricles (90% each), varicose veins of the lower extremities (33.3%) and easy formation of hematomas at insignificant damage (20%). Correlations were found in women with UCTD between the number of markers and the frequency of detection of the diagonal fold of the earlobe (r=+0.79; p<0.05), blue sclera (r=+0.77; p<0.05), radial-lacunar type of iris (r=+0.66; p<0.05), varicose veins of the lower extremities (r=+0.73; p<0.05) and easy formation of hematomas at insignificant damage (r=+0.51; p<0.05). Thus, the above markers of UCTD can be considered as prognostic criteria for the complicated course of CHD, which will allow further development of new approaches to the detection of such individuals and their differentiated therapy.