The impact of B vitamins on the functioning of methylation cycle in the liver and the kidneys of hyper- and hypothyroid rats

Nechyporuk, V.; Korda, M.; Pentiuk, L.; Dmytrenko, I.; Bulko, I.

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Кафедра медичної та біологічної хімії
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Наукові публікації каф. медичної та біологічної хімії
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dc.contributor.author	Nechyporuk, V.
dc.contributor.author	Korda, M.
dc.contributor.author	Pentiuk, L.
dc.contributor.author	Dmytrenko, I.
dc.contributor.author	Bulko, I.
dc.date.accessioned	2025-03-20T18:08:33Z
dc.date.available	2025-03-20T18:08:33Z
dc.date.issued	2020
dc.identifier.citation	Nechyporuk V. The impact of B vitamins on the functioning of methylation cycle in the liver and the kidneys of hyper- and hypothyroid rats / V. Nechyporuk, M. Korda, L. Pentiuk [et al ] // Pol Merkur Lekarski. – 2020. – 48(283). – C. 55-59	uk_UA
dc.identifier.other	PMID: 32218408
dc.identifier.uri	https://dspace.vnmu.edu.ua/123456789/8441
dc.description.abstract	Hyperhomocysteinemia is a risk factor for endothelial dysfunction and, consequently, for cardiovascular disease and multiple other conditions. Impairment of homocysteine metabolism is known to occur in thyroid dysfunction. In particular, patients with hypothyroidism have significantly higher homocysteine levels than healthy people. Metabolism of homocysteine occurs in methylation cycle (whose normal functioning is dependent on tissue pools of vitamins B9, B12 and betaine), and also in reactions of trans-sulfonation, where pyridoxal phosphate (a pyridoxine derivative) acts as a coenzyme	uk_UA
dc.language.iso	en	uk_UA
dc.publisher	Polski merkuriusz lekarski	uk_UA
dc.subject	remethylation cycle	uk_UA
dc.subject	betaine	uk_UA
dc.subject	homocysteine	uk_UA
dc.subject	hyperthyroidism	uk_UA
dc.subject	hypothyroidism	uk_UA
dc.subject	vitamins B9, B12 and B6	uk_UA
dc.title	The impact of B vitamins on the functioning of methylation cycle in the liver and the kidneys of hyper- and hypothyroid rats	uk_UA
dc.type	Article	uk_UA