Objectives: In early human pregnancy placental trophoblasts migrate along uterine spiral arteries (SAs) and remodel these vessels into wide-bore conduits in a process essential for successful pregnancy. This work examined ...

Hypertensive disorders of pregnancy are a leading cause of maternal morbidity and mortality worldwide, accounting for more than 70,000 maternal deaths each year. Of all maternal deaths, 10–15% are directly associated with ...

Transformation of uterine spiral arteries (SAs) is critical for healthy human pregnancy. Endothelial damage and dysfunction are common features of all of the pathological features of pre-eclampsia, stimulating the activation ...

Low-dose aspirin (ASA) has been used during pregnancy, most commonly to prevent or delay the onset of preeclampsia. The Ukrainian National clinical guideline (2022) recommending daily 100-150mg from 12 weeks of gestation ...

The author presents the results of studying the influence of the preventive treatment by the levels of soluble forms of vascular cell adhesion molecule-1 (s-VCAM-1) and platelet endothelial cell adhesion moleculae-1 ...

Despite a significant volume of literature regarding placental dysfunction in PE, data regarding the cardiac changes associated with PE are more scant, and also more controversial. The conventional belief was that early ...

The aim: To investigate role of CD23, VEGF and PP13 in diagnostics of early and late preeclampsia, and their benefit for prediction of preeclampsia. Materials and methods: Investigation included 40 placentas from deliveries ...

The fibrinolytic imbalance might have a pivotal role in hypercoagulability seen in gestational endotheliopathy. Our objective was to determine the novel fibrinolytic markers of blood coagulation related factors in placental ...