Morphological changes in kidney tissues of rats with acute ethanol-induced injury and after drug correction

Abstract

Kidneys perform excretory function and regulate the work of many systems of the body, therefore, the morphological changes of the functional apparatus of the kidneys must necessarily affect the functions of other organs and systems. Data on pathological processes in the kidneys caused by the action of ethanol are diverse and can be manifested as universal tissue reactions to the action of ethanol and manifestations of its toxic effects directly on the tissue of the kidney. Aim: to study the morphological changes in kidney tissues of rats with acute ethanol-induced injury and correction with quercetin and L-arginine L- glutamate. Experimental studies performed on 66 white non-linear, sexually mature male rats weighing 120-130g (average weight - 125 g). Acute alcoholic defeat was modeling by intragastric 273 administration of 40% ethanol in a dose of 20 ml/kg for 7 days with the help of a metal probe with oil. The revealed changes in renal tissue can be considered valuable morphological criteria that characterize the damage of the renal parenchyma in acute alcohol defeat. Using of the preparations of quercetin and L-arginine L-glutamate promotes the protection of kidney cells from the toxic effects of ethanol, which manifested itself in decreasing the severity of dystrophic changes in the endothelium of the tubules. The performed morphological study allows verifying more pronounced tread effect in the form of improving the histostructure of the kidneys under the combination of both drugs in comparison with monotherapy.