Короткий опис (реферат):
An important role in the development of acne is played by the activity of the skinmicroflora (namely the bacteria Propionibacterum acnes) and members of the genusStaphylococcus. In the schemes of complex treatment of patients with this disease,antibiotics from among macrolides or lincosamides are mainly used. It is of interest tostudy the current state of susceptibility of staphylococci and propionic bacteria tothese drugs, as well as to other antimicrobial agents in order to determine the prospectsfor expanding the arsenal of methods for treating acne. The aim of the study was tostudy the susceptibility of microorganisms involved in the development of acne toantimicrobials and antagonistic effects of probiotic strains of lactobacilli. We conducteda bacteriological study of the content of rash elements in 60 patients with acne. Thebiological characteristics of 40 strains of Staphylococcus spp. and 15 strains ofPropionibacterum acnes isolated and researched. The sensitivity of microorganismsto antibiotics and antiseptics was determined by the disco-diffusion method and themethod of serial double dilutions of drugs in a liquid nutrient medium. Determination ofthe sensitivity of acne pathogens to the antagonistic effect of lactobacilli was performedby the method of two-layer agar by reducing the number of microorganisms. Theresults of the study made it possible to establish that the isolated strains of bacteriashow a low level of sensitivity to antimicrobials, which in medical practice are mostoften used for topical therapy of acne. Only 17.5 % of isolated staphylococcal strainswere sensitive to erythromycin, only 45.0 % of strains of this species were sensitive toclindamycin. Strains of Propionibacterum acnes showed a higher level of sensitivity toantibiotics than staphylococci. However, the established indicators do not allow toconsider highly effective means for treatment of acne on their basis. At the same time,a high level of sensitivity of acne pathogens to antiseptic drugs decamethoxine andAeroplysinin 1 and antagonistic effect of Lactobacillus acidophilus was established.Thus, the strains of Propionibacterum acnes and Staphylococcus spp., involved in thedevelopment of acne, are characterized by high levels of resistance to erythromycin,clindamycin, chloramphenicol, benzoyl peroxide, which are now the basis of the arsenalof topical therapy for patients with this disease. There is a need to find new effectivedrugs for the etiotropic therapy of acne
