Короткий опис (реферат):
Skin diseases are a significant socio-economic problem, as their diagnosis and treatment in the United States alone costs $ 75 billion annually. About 900 million people worldwide suffer from them. In addition to the high cost of their treatment, they cause moral and physical discomfort to patients, impair their social activity, lead to disability, and even death. It should also be noted that this group of diseases is one of the most common in the world. In turn, the peak in prevalence in this cohort of pathologies is acne. This is a chronic inflammatory disease of the sebaceous glands of the skin, manifested by a rash formed by papules and pustules, after the regression of which may remain atrophic scars, which has a negative cosmetic effect. The main site of localization is the skin of the face, torso, and upper extremities. Acne affects people between the ages of 12 and 24, due to hormonal changes in the body during puberty, but also occurs in people aged 30-40. It has also been observed that women get sick more often, but a more severe course is observed in men. Another important pathology is atopic dermatitis. It is a chronic inflammatory skin disease that often relapses and is associated with other atopic manifestations such as asthma, food allergies, and allergic rhinitis. It mainly affects children, about 15-20%, and 2-3% of the adult population worldwide. It should also be noted that the incidence of the disease over the past 50 years has increased 2-3 times in developed countries. Although the etiology and pathogenesis of these diseases are not related, several studies have found that polymorphism of the TNF-α gene can affect the predisposition to their development and severity.
