Morphological structure and changes of the renal cell cycle in chronic kidney disease and its correction with hydrogen sulphide and genistein

Voloshchuk, N. I.; Korol, A. P.; Denysiuk, O. M.; Pashinska, O. S.; Taran, I. V.; Sayenko, A. V.; Nefodov, O. O.

dc.contributor.author	Voloshchuk, N. I.	en
dc.contributor.author	Korol, A. P.	en
dc.contributor.author	Denysiuk, O. M.	en
dc.contributor.author	Pashinska, O. S.	en
dc.contributor.author	Taran, I. V.	en
dc.contributor.author	Sayenko, A. V.	en
dc.contributor.author	Nefodov, O. O.	en
dc.date.accessioned	2025-03-16T16:39:54Z
dc.date.available	2025-03-16T16:39:54Z
dc.date.issued	2023
dc.identifier.citation	Voloshchuk N. I. Morphological structure and changes of the renal cell cycle in chronic kidney disease and its correction with hydrogen sulphide and genistein / N. I. Voloshchuk, A. P. Korol, O. M. Denysiuk [et al.] // World of Medicine and Biology. – 2023. – Vol. 19 (84). – P. 191-196.	en
dc.identifier.other	DOI: 10.26724/2079-8334-2023-2-84-191-196
dc.identifier.uri	https://dspace.vnmu.edu.ua/123456789/7668	en
dc.description.abstract	The purpose of the study was to establish the effect of hydrogen sulfide and genistein on cell cycle indicators and histomorphological changes in kidneys under conditions of experimental chronic kidney disease. In sexually mature white nonlinear rats, the pathology was modelled by unilateral nephrectomy and subtotal (5/6) resection of the contralateral kidney. Cytometric parameters and renal morphological changes were evaluated after 40 days by DNA flow cytometry and light microscopy, respectively. It was established that the use of the hydrogen sulfide donor NaHS, as well as genistein, showed a pronounced nephroprotective effect due to the antiapoptotic effect, the normalization of the number of mitoses and the activity of DNA synthesis, inhibition of the development of structural and degenerative-dystrophic changes in the kidneys, activation of compensatory-adaptive and regenerative processes and normalization of hemodynamics. This can become the basis for developing more effective pharmacotherapy for chronic kidney disease.	en
dc.language.iso	en	en
dc.publisher	Світ медицини та біології	uk_UA
dc.subject	chronic kidney disease	en
dc.subject	hydrogen sulfide	en
dc.subject	nephroprotective action	en
dc.subject	plant polyphenols	en
dc.subject	genistein	en
dc.subject	rats	en
dc.subject	morphological structure	en
dc.subject	flow cytometry	en
dc.title	Morphological structure and changes of the renal cell cycle in chronic kidney disease and its correction with hydrogen sulphide and genistein	en
dc.title.alternative	Морфологічна структура та зміни клітинного циклу в нирках за хронічної хвороби нирок та її корекції гідроген сульфідом і геністеїном	uk_UA
dc.type	Article	en