Cluster analysis revealed antibiotics with the highest efficacy against bacteria isolated from patients with infectious and inflammatory diseases of the soft tissues of the facial area

Abstract

Background: Incorrect prescription of antibiotics in dental surgery leads to the acquisition of antibiotic resistance of microorganisms. Aim: The aim of the given study was to conduct a retrospective cluster analysis of antibacterial drugs according to their efficacy against bacteria isolated from patients with infectious inflammatory diseases of the facial soft tissue. Materials and methods: The cross-sectional study involved 351 patients who were treated for in the department of maxillofacial surgery during 2019 – 2022. Results and conclusions: According to the results of cluster analysis, clinical isolates of S. aureus isolated from foci of infectious and inflammatory diseases of the facial soft tissue retain sensitivity to vancomycin, moxifloxacin, ciprofloxacin, levofloxacin, norfloxacin and cefoxitin. Coagulase-negative Staphylococcus spp. are most sensitive to norfloxacin, erythromycin, azithromycin, benzylpenicillin, kanamycin, gentamicin and clindamycin and Enterococcus ssp. to norfloxacin and tigecycline. Kocuria, Streptococcus, drug S. viridans isolates retained a stable sensitivity only to vancomycin in a retrospective analysis.