Sensitivity of causative agents of infectious-inflammatory diseases in maxillofacial soft tissues to antibiotics

Abstract

The aim of this study is to investigate the sensitivity of pathogens causing infectious and inflammatory diseases in soft tissues within the maxillofacial region to antibiotics. The study was performed on 282 clinical isolates collected from patients. The sensitivity of the microorganisms to antibiotics was evaluated based on the EUCAST committee quality control standards. The variability in the sensitivity of microorganisms isolated from patients with infectious and inflammatory diseases of the maxillofacial soft tissues to antibiotics has been determined. Representatives of the genus Staphylococcus exhibit high sensitivity to vancomycin,fluoroquinolones and lincosamides. At the same time, they are characterized by the lowest sensitivity to aminglicosites and penicillins. Enterococcus spp. has high sensitivity to tetracyclines and fluoroquinolones, showing the lowest results with penicillins and carbapenems. Streptococcuss spp. viridans-group show low sensitivity to penicillins, carbapenems, fluoroquinolones, and lincosamides, while maintaining high sensitivity to glycopeptides. Low sensitivity of Acinetobacter spp. isolated from patients with infectious and inflammatory diseases of maxillofacial soft tissues to antibacterial drugs of different groups has been revealed. The study has shown e significant variation in the sensitivity of isolates to antibiotics commonly used in clinical practice and recommended by the EUCAST quality committee, suggesting the prospects for their use.