The role of microbial wound contamination in chronic pain development in patients with injuries

Abstract

Nowadays, with the start of hostilities in Ukraine, the number of people with injuries has increased and continues to grow. Of course, one of the main issues facing by medical professionals is preventing complications and restoring sufficient functional capacity. Pain is one of the protective mechanisms of the human body; its prolonged course is one of the most important causes for reducing the quality of life and limiting a person’s work capacity. Acute pain is positioned as the body’s main signal for help, usually as a disease symptom, while chronic pain can be an independent nosological unit and mostly appears after primary cause. Secondary chronic pain is one of the injury consequences that can occur and significantly worsen the patient’s prognosis and reduce quality of life. Prevention of the secondary chronic pain is possible if all prerequisites are known. Furthermore, the human body interacts with a complex community of bacteria, fungi, and viruses. Several microorganisms create the microbiome of the skin, which ensures its barrier function and plays an important role in the immune response in wounds. These processes are not always predictable, and both positive and negative effects on wound healing can be observed. After all, the duration of wound healing directly depends on the type of microorganisms and their sensitivity to the antibiotic treatment. The long process of wound surface healing can lead more likely to a violation of all physiological processes in this body part. This can be quite an important factor in chronic pain occurrence