Evaluation of the hepatotoxic effect of unreasonable antibiotic therapy among patients in the pre-jaundice period of viral hepatitis A

Abstract

Despite its predominant gastrointestinal localization, the onset of viral hepatitis A (HAV) in most cases is characterized by extra-hepatic manifestations (in 98%—flu-like syndrome in the pre-jaundice period), which complicates timely diagnosis in the primary care, leads to erroneous and unreasonable prescription of antibiotics and therefore creates favourable conditions for formation of antibiotic-resistant strains.