Prevalence of rs4986790 (Asp299Gly) polymorphism of the TLR-4 gene in patients with acute brucellosis depending on the damage to the hepatobiliary system

Abstract

Human genetic factors play an important role in the present stage of studying new aspects of the pathogenetic mechanisms of development, course, and outcomes of infectious diseases. Some studies established that the Asp299Gly polymorphism of the TLR-4 gene, which is currently associated with a variety of diseases, is of clinical importance. The article presents the results of an examination of 120 patients with acute brucellosis. The diagnosis of brucellosis was made based on complaints, anamnesis, epidemiologic and clinical data, and the results of specific examinations. The Asp299Gly polymorphism of the TLR-4 gene was determined in all patients. A detailed characterization of patients with brucellosis has been presented. Young, working-age men prevailed among the examined persons. Carriers of the G allele of the polymorphic (Asp299Gly) TLR-4 gene were found to have an increased risk of acute brucellosis with liver damage (OR=12.76, 95% CI [4.25–38. 29]), and in the case of carrying the A allele, on the contrary, they had a decreased risk of acute brucellosis with liver damage (OR=0.0895% CI [0.03–0.24]) model significant at χ2 =27.87P < 0.0001). Carriage of homozygous genotype A/A had a protective effect against the development of acute brucellosis with signs of liver damage (OR =0.0295% CI [0.01–0.07]).