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dc.contributor.author Mykhailenko, O. en
dc.contributor.author Lesyk, R. en
dc.contributor.author Finiuk, N. en
dc.contributor.author Stoika, R. en
dc.contributor.author Yushchenko, T. en
dc.contributor.author Ocheretniuk, A. en
dc.contributor.author Vaschuk, V. en
dc.contributor.author Mishchenko, V. en
dc.contributor.author Georgiyants, V. en
dc.date.accessioned 2023-07-03T13:00:31Z
dc.date.available 2023-07-03T13:00:31Z
dc.date.issued 2020
dc.identifier DOI: 10.7324/JAPS.2020.10708 en
dc.identifier.citation In vitro anticancer activity screening of Iridaceae plant extracts / O. Mykhailenko, R. Lesyk, N. Finiuk [at al.] // Journal of Applied Pharmaceutical Science. – 2020. – Vol. 10 (7). – Р. 59–63. en
dc.identifier.uri https://dspace.vnmu.edu.ua/123456789/6228 en
dc.description.abstract The different effects on human tumor cells (MCF-7, HepG2, HCT116, HeLa, HL-60, and HaCaT) for Ukrainian plant extracts have been examined for the first time. The extracts were from Crocus sativus (stigma, flowers, leaves, and corms), Juno bucharica (leaves), Gladiolus hybrid Zefir (leaves), and Iris hungarica (rhizomes) from Iridaceae family. All the studied extracts exhibited in vitro dose- and time-dependent killing capabilities on applied tumor cell lines. Their killing activity was tissue specific toward tumor cells. The HL-60 acute promyelocytic leukemia cell line and HCT116 colon adenocarcinoma cell line were found as the most sensitive toward treatment with studied plant extracts. It was found that the extracts were not active against normal human epidermal keratinocytes of the HaCaT line. Gladiolus leaf extract showed particularly strong anticancer properties in vitro. The current results for the first time suggest that Iridaceae plant water dry extracts are promising anticancer reagents. Subsequently, the results can be used to develop a prevention agent for the treatment of human cancers. en
dc.language.iso en en
dc.subject anti-cancer activity en
dc.subject iridaceae en
dc.subject dry extracts en
dc.title In vitro anticancer activity screening of Iridaceae plant extracts en
dc.type Article en


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